Early vs. Late decompressive craniectomy in pediatrics with traumatic brain injuries: A retrospective study.

Background: Severe traumatic brain injury (TBI) is a leading cause of mortality and disability in pediatric patients, especially in low and middle-income countries. TBI significantly impacts child development and incurs substantial healthcare costs. Management of severe TBI includes evidence-based protocols to prevent and treat increased intracranial pressure, with decompressive craniectomy (DC) as a rescue measure.

Discovery of New HER2 Inhibitors via Computational Docking, Pharmacophore Modeling, and Machine Learning.

The human epidermal growth factor receptor 2 (HER2) is a critical oncogene implicated in the development of various aggressive cancers, particularly breast cancer. Discovering novel HER2 inhibitors is crucial for expanding therapeutic options for HER2-related malignancies. In this study, we present a computational workflow that focuses on generating pharmacophores derived from docked poses of a selected list of 15 diverse, potent HER2 inhibitors, utilizing flexible docking.

Impact of sub-chronic exposure to Kalach on male reproductive system and sperm function: In silico modelling and in vivo study in rats.

Kalach 360 SL (KL), a glyphosate-based herbicide, is among the most widely used herbicides in Tunisia. This study aimed to evaluate the impact of sub-chronic exposure to KL on the male reproductive system and sperm parameters in adult rats after one and two cycles of spermatogenesis. 15 rats were randomly divided into three groups: a control group (G1) and two experimental groups (G2 and G3), exposed to KL at a dose of 102.

Reliability of an Electronic Uterine Diagram to Standardize Intrauterine Adhesion Scoring.

Study Objective: To study the inter-rater reliability of an electronic complementary uterine diagram (electronic American Fertility Society [eAFS] freely available at https://bit.ly/eAFS-score) in comparison with the conventional American Fertility Society (cAFS) intrauterine adhesion (IUA) scoring system. As a secondary aim, we wanted to assess the intra-rater reliability of these tools.

A Soft Tissue-Borne Patient-Specific Guide for Foreign Body Removal in the Facial Region.

Foreign body removal in the facial region poses significant challenges due to the complex anatomy and the proximity to critical structures. This study introduces a soft tissue-borne patient-specific guide (PSG) designed to enhance precision and minimize invasiveness in foreign body removal. Four patients underwent foreign body removal using PSGs, with CT and cone-beam computed tomography (CBCT) imaging employed for segmentation and detailed analysis of both hard and soft tissues.