Combination checkpoint blockade and laser interstitial thermal therapy in radiographically progressive non-small cell lung cancer brain metastases.

Background: Laser interstitial thermal therapy (LITT) is a minimally invasive surgical treatment being employed frequently for radiographically progressive brain metastases. Considerable interest exists in combining LITT-mediated in situ vaccination to license immune checkpoint blockade (ICB). No studies have examined the clinical feasibility of this combination in brain metastases.

Developing entrustable professional activities for undergraduate operative dentistry clerkship.

Objective: In many dental schools worldwide, theoretical knowledge is prioritized over comprehensive training in essential clinical procedures. This leads to graduates with insufficient hands-on experience who are not fully "ready to practice", thereby failing to meet the demands of the job market and community needs. This study aimed to address this critical gap by developing and validating a set of core Entrustable Professional Activities (EPAs) specifically for operative dentistry clerkships to enhance the practical competencies and readiness of dental graduates for effective and independent practice.

Exploring medical educators' perspectives on teaching effectiveness and student learning.

Background: Medical education in resource-constrained settings such as Pakistan faces significant challenges, including large class sizes, limited resources, and reliance on traditional teacher-centered pedagogies. These factors hinder effective learning and fail to equip students with the critical thinking and practical skills essential for modern medical practice. Educators play a fundamental role in shaping student experiences but often struggle to adopt student-centred methodologies due to insufficient training, resource limitations, and institutional constraints.

From quantum communication fundamentals to decoherence mitigation strategies: Addressing global quantum network challenges and projected applications.

In the aftermath of unparalleled disruptive technologies, the quantum realm has become a fundamental field of research due to unrivaled computational power and super-secure communication. In addition to conventional networks, a new word in the quantum domain is quantum network. The quantum network uses quantum communication (QC) to send quantum information bits known as qubits, to predetermined destination nodes.

Role of Multimodality Imaging in Cardiac Sarcoidosis: A Retrospective Single-Center Experience.

Cardiac sarcoidosis (CS) is a rare entity characterized by granulomatous infiltration of the myocardium, which can lead to myocardial fibrosis, conduction abnormalities, and the development of heart failure, thereby elevating the risk of sudden cardiac death (SCD). While endomyocardial biopsy (EMBx) is regarded as the gold standard for diagnosis, its low sensitivity and inherent procedural risks may limit its practical application. This study retrospectively explored the role of advanced imaging modalities, specifically cardiovascular magnetic resonance imaging (CMR) and fluorodeoxyglucose positron emission tomography (FDG-PET), in the diagnosis and management of CS within a single center.