Publications by authors named "S Danneberg"

Article Synopsis
  • Minimal hepatic encephalopathy (MHE) is linked to a greater risk of overt hepatic encephalopathy (OHE) as measured by the portosystemic hepatic encephalopathy score (PHES).
  • A multicenter study followed patients with MHE to see if worse PHES results led to a progressively higher risk of developing OHE.
  • Findings showed that while abnormal PHES indicates a higher chance of OHE, there isn't a stepwise increase in risk as PHES scores worsen beyond a certain threshold.
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Background And Aims: Minimal hepatic encephalopathy (MHE) is a frequent complication in patients with liver cirrhosis. Its impact on predicting the development of overt hepatic encephalopathy (OHE) and survival has not been studied in large multicenter studies.

Methods: Data from patients recruited at eight centers across Europe and the United States were analyzed.

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Article Synopsis
  • A study aimed to determine the prevalence of minimal hepatic encephalopathy (MHE) in different patient subgroups suffering from cirrhosis, to better identify those at higher risk.
  • The research involved 1,868 patients from 10 centers in Europe and the U.S. and found that 35% had MHE, with notable variations based on liver disease severity.
  • Results showed lower prevalence in early-stage cirrhosis (CP A at 25%) compared to advanced stages (CP B at 42% and CP C at 52%), suggesting the need for personalized screening strategies based on disease stage and MELD scores.
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Background & Aims: Blood biomarkers facilitating the diagnosis of covert hepatic encephalopathy (CHE) in patients with cirrhosis are lacking. Astrocyte swelling is a major component of hepatic encephalopathy. Thus, we hypothesised that glial fibrillary acidic protein (GFAP), the major intermediate filament of astrocytes, might facilitate early diagnosis and management.

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