Publications by authors named "S Danielle Macneil"
Background: Understanding vascular development and the key factors involved in regulating angiogenesis-the growth of new blood vessels from pre-existing vasculature-is crucial for developing therapeutic approaches to promote wound healing. Computational techniques offer valuable insights into improving angiogenic strategies, leading to enhanced tissue regeneration and improved outcomes for chronic wound healing. While chorioallantoic membrane (CAM) models are widely used for examining fundamental mechanisms in vascular development, they lack quantification of essential parameters such as blood flow rate, intravascular pressure, and changes in vessel diameter.
View Article and Find Full Text PDFInterspecies differences in human, pig and sheep corneal thickness may affect the colonization. Currently, there is no research investigating the impact of these differences, along with variable storage and culture conditions on infection in cornea models. These factors could significantly influence utilizing models for drug testing research.
View Article and Find Full Text PDFArticle Synopsis
- - The study addresses complications seen in women after polypropylene mesh surgery for urinary incontinence, highlighting the need for a preclinical animal model for better assessment before human trials.
- - Fourteen ewes were surgically implanted with either polypropylene or polyurethane tape to simulate the procedure, while post-operative assessments included monitoring for pain and complications.
- - The results indicated a successful procedure with no complications observed, marking this as the first significant large animal model aimed specifically at understanding suburethral mesh implantation.
Background: This ORATOR sub-study evaluated swallowing physiology in patients treated with transoral robotic surgery (TORS) versus radiotherapy (RT) for early-stage oropharynx cancer.
Methods: Swallowing physiology was evaluated using videofluoroscopy and outcomes were compared across treatment arms and correlated with MDADI scores.
Results: Of the 68 patients in the ORATOR trial, 21 participated in this sub-study (30.