Publications by authors named "S Da Ros"
Article Synopsis
- High grade serous ovarian cancer has two metabolic subtypes: a high OXPHOS subtype that is more chemosensitive and a low OXPHOS subtype that relies on glycolysis and is more drug resistant.
- The low OXPHOS subtype shows higher levels of lactate dehydrogenase and monocarboxylate transporter 4, indicating different metabolic behaviors compared to the high OXPHOS subtype.
- Two imaging techniques, C magnetic resonance spectroscopy and PET scans, can differentiate between these subtypes and track their treatment responses, offering potential clinical applications for patient management.
Introduction: Integrated care pathways (ICPs) are crucial for delivering individualised care. However, the development of ICPs is challenging and must be well designed to provide the expected benefits. Regarding this, healthcare organisations are increasingly adopting management systems based on Lean Thinking to improve their organisational processes by eliminating non-value-added steps.
View Article and Find Full Text PDFPsoriasis is a chronic skin disease that negatively impacts on patient's life. A holistic approach integrating well-being assessment could improve disease management. Since a consensus definition of well-being in psoriasis is not available, we aim to achieve a multidisciplinary consensus on well-being definition and its components.
View Article and Find Full Text PDFPurpose: Transcriptomic subtyping holds promise for personalized therapy in extensive-stage small cell lung cancer (ES-SCLC). In this study, we aimed to assess intratumoral transcriptomic subtype diversity and to identify biomarkers of long-term chemoimmunotherapy benefit in human ES-SCLC.
Experimental Design: We analyzed tumor samples from 58 patients with ES-SCLC enrolled in two multicenter single-arm phase IIIb studies evaluating frontline chemoimmunotherapy in Spain: n = 32 from the IMfirst trial and n = 26 from the CANTABRICO trial.