In Quest of Pathognomonic/Endophenotypic Markers of Attention Deficit Hyperactivity Disorder (ADHD): Potential of EEG-Based Frequency Analysis and ERPs to Better Detect, Prevent and Manage ADHD.

Attention deficit hyperactivity disorder (ADHD) is a chronic heritable developmental delay psychiatric disorder requiring chronic management, characterized by inattention, hyperactivity, hyperkinectivity and impulsivity. Subjective clinical evaluation still remains crucial in its diagnosis. Discussed are two key aspects in the "characterizing ADHD" and on the quest for objective "pathognomonic/endophenotypic diagnostic markers of ADHD".

Early noninvasive diagnosis of neurodegenerative diseases.

This paper reviews the contemporary trends in the pathobiochemistry of neurodegenerative disorders with respect to their early predictive diagnosis and possible treatment interventions. If we consider the current epidemiological data related to neurodegenerative disorders, medicine is going to face in the near future latent pandemic situations. The introduction puts an emphasis on the emerging importance of one major cluster of neurodegenerative disorders: diseases of the abnormal protein beta-conformation.

Overweight, dyslipoproteinemia, and heart rate variability measures.

Unlabelled: Chronic stress could be a risk factor triggering, aggravating or causing overweight, dyslipoproteinemia and coronary artery disease.

Objective: The purpose of this study was to determine the association between stress assessed by heart rate variability measures, dyslipoproteinemia, and overweight.

Methods: Total cholesterol, high and low density lipoproteins cholesterol and triglycerides were analyzed by enzyme methods; heart rate variability was evaluated using a computer program for analysis of cardiointervals in 47 individuals with dyslipoproteinemia.

The "cost" of silence.

Changes in the organism of control desk operators caused by difficulties faced during productionally relevant speech information processing under conditions of intense occupational noise, represent the psychophysiological "cost" of noise masking. Its presence attests to difficulties in processing before deterioration of the quality of the latter while its quantitative characterisation correlates positively with the degree of the masking effect of noise and with the neuropsychic stress of this particular type of work. For this reason an attempt is made to demonstrate noise masking under laboratory conditions with it approximate quantitative evaluation at two signal/noise ratios- +15 and The statistically significant differences between the values of pulse rate, plethysmography and vocal exertion at the above ratios point to both its presence, and to the necessity to be considered when assessing the occupational burden and standardisation of noise intensity in productions associated with speech signals.