Publications by authors named "S D Zangwill"
Article Synopsis
- The study investigates the use of mechanical circulatory support (MCS) in pediatric heart transplant patients, focusing on incidence, contributing factors, and outcomes based on a large database from 2010-2020.
- Among 4,321 primary heart transplants analyzed, 5.8% (249 patients) required MCS, with factors like congenital heart disease and older donor age linked to higher MCS need, while larger recipient size and better donor heart function correlated with lower needs.
- The one-year survival rate for patients requiring MCS was significantly lower at 54.2% compared to 94.8% for those without, but those who survived the first year had favorable long-term outcomes, suggesting selective use of MCS
Background: The aims of the study were to assess the performance of a clinically available cell-free DNA (cfDNA) assay in a large cohort of pediatric and adult heart transplant recipients and to evaluate performance at specific cut points in detection of rejection.
Methods: Observational, non-interventional, prospective study enrolled pediatric and adult heart transplant recipients from seven centers. Biopsy-associated plasma samples were used for cfDNA measurements.
Prinzmetal angina is a rare cause of intermittent chest pain in paediatrics. Here, we report the case of a 2-year-old female who presented with episodic chest pain, malaise, diaphoresis, fatigue, and poor perfusion on exam. During her hospitalisation, these episodes were associated with significant low cardiac output as evidenced by lactic acidosis and low mixed venous oxygen saturations.
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- Fontan associated liver disease (FALD) can affect heart transplant outcomes in Fontan patients; this study examined pre-transplant risk factors and post-transplant liver recovery at 12 pediatric hospitals from 2001-2019.
- Out of 156 Fontan patients, common reasons for transplantation included decreased heart function and protein losing enteropathy, with a 5-year survival rate of 73%; pre-transplant high bilirubin levels indicated a higher risk of death.
- Advanced liver fibrosis did not predict death post-transplant, but liver imaging suggested some improvement in liver condition after the heart transplant procedure.