[Microcirculatory disorders in the early period of autotoxic shock].

Microcirculation in the rat mesenterium was studied in the early period of autotoxic shock, using light and electron microscopy. Progressive reduction in the number of functioning capillaries, blood flow slowing in microvessels, and increase in the number of leukocytes that adhere to the luminal surface of the endothelium have been noted. Cases of stasis, sludge syndrome, thrombosis of small venules and disturbances of vascular permeability for protein have been observed.

[Use of liposomes to demonstrate the function of the mononuclear phagocyte system].

The possibility of using liposomes containing an indicator composition (dye or fluorophor) for the determination of the eliminative activity of the system of mononuclear phagocytes (SMP) was studied. Liposomes were obtained by the sonication of the suspension of lecithin, cholesterol and an indicator substance. The rate of the elimination of liposomes from the blood stream after their intravenous injection into Wistar rats (males) was evaluated photometrically or fluorometrically in hemolyzed blood samples taken from the animals at different periods after the injection.