Publications by authors named "S D Small"
Introduction: Patients with blunt chest wall injuries and rib fractures are known to have high rates of atelectasis, pneumonia, pulmonary contusion, and can develop acute respiratory distress syndrome. This can lead to ventilator requirement and dependence, deconditioning secondary to uncontrolled pain, and increased hospital length of stay (LOS). Many studies in the literature have developed triage algorithms in patients with rib fractures to guide disposition and management, and several institutions have gone on to describe their institution-specific management protocols to decrease complications related to traumatic rib fractures.
View Article and Find Full Text PDFAnthracyclines, such as doxorubicin, are important anti-cancer therapies but are associated with arterial injury. Histopathological insights have been limited to small animal models, and the role of inflammation in the arterial toxic effects of anthracycline is unclear in humans. Our aims were (1) to evaluate aortic media fibrosis and injury in non-human primates treated with anthracyclines; (2) to assess the effect of anthracycline on aortic inflammation in patients treated for lymphoma.
View Article and Find Full Text PDFArticle Synopsis
- Advances in brain imaging and data analysis have shifted medical diagnosis from traditional methods to data-driven approaches, enhancing understanding of neurological diseases.
- Randomized controlled trials (RCTs) have led to the development of new treatments, but now there's a focus on precision medicine that personalizes care based on individual genetic and phenotypic data.
- The article explores how integrating genomic, phenomic, imaging, and behavioral data can refine neurological treatments and improve value-based care in medicine.
Article Synopsis
- A study was conducted to investigate the X-chromosome's role in Alzheimer's Disease (AD), which had been overlooked in previous genome-wide association studies.
- The research included 115,841 AD cases and 613,671 controls, considering different X-chromosome inactivation (XCI) states in females.
- While no strong genetic risk factors for AD were found on the X-chromosome, seven significant loci were identified, suggesting areas for future research.