Role of alkaline barriers in radionuclide distribution in river valley environments on the Russian Black Sea coast.

This paper reports on the radioecological properties of environmental components in the Mzymta and Sochi River valleys on the Russian Black Sea coast. The environmental components covered are river sediments, alluvial soils, mosses, and fluvial water. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) was used to determine the distribution patterns of Th and U stemming from two geochemical alkaline barriers present in the river valleys.

Postfermentation of Fireweed and Apple Tree Leaf Herbal Teas.

Fungi spp. are the main biological agents that ferment the leaves of the tea bush to form a popular food product, postfermented tea. The fungus , stored in the collection of the Gause Institute of New Antibiotics under the number INA 01267, was isolated and identified from a briquette of Fujian Chinese tea.

Nucleophilic dearomatization of 4-aza-6-nitrobenzofuroxan by CH acids in the synthesis of pharmacology-oriented compounds.

4-Aza-6-nitrobenzofuroxan (ANBF) reacts with 1,3-dicarbonyl compounds and other CH acids to give carbon-bonded 1,4-adducts - 1,4-dihydropyridines fused with furoxan ring. In the case of most acidic β-diketones, which exist mainly in the enol form in polar solvents, the reactions proceed in the absence of any added base emphasizing the highly electrophilic character of ANBF. The resulting compounds combine in one molecule NO-donor furoxan ring along with a pharmacologically important 1,4-dihydropyridine fragment and therefore can be considered as prospective platforms for the design of pharmacology-oriented heterocyclic systems.

[Nitrobenzofuroxane derivatives as dual action hiv-1 inhibitors].

Human immunodeficiency virus first type (HIV-1) is a main cause of one of the most dangerous diseases, AIDS. The search for new inhibitors of the virus still remains an urgent task. One approach to suppress the HIV infection is to use a double-acting inhibitors, i.

Structural-Functional Analysis of 2,1,3-Benzoxadiazoles and Their N-oxides As HIV-1 Integrase Inhibitors.

Human immunodeficiency virus type 1 integrase is one of the most attractive targets for the development of anti-HIV-1 inhibitors. The capacity of a series of 2,1,3-benzoxadiazoles (benzofurazans) and their N-oxides (benzofuroxans) selected using the PASS software to inhibit the catalytic activity of HIV-1 integrase was studied in the present work. Only the nitro-derivatives of these compounds were found to display inhibitory activity.