Publications by authors named "S D Schwartz"
In 2022, the catchment area of the Fred Hutchinson/University of Washington/Seattle Children's Cancer Consortium (the Consortium) grew from 13-counties in Western Washington State to include all 39 counties in Washington. Widening the catchment area provided new opportunities for the Consortium to monitor the cancer burden, identify cancer-related health disparities, use a bidirectional approach to develop cancer focused programming, and facilitate research in clinical and community settings. In this commentary, we describe the exploratory process of catchment area change led by the Consortium's Office of Community Outreach and Engagement and new initiatives that followed that growth.
View Article and Find Full Text PDFAnomalous pulmonary vein drainage is a rare but clinically relevant variant of the cardiovascular anatomy. We present a case report of a 22-year-old male who was incidentally found to have anomalous pulmonary vein drainage into the innominate vein. The patient had a known history of seizures and was brought to the emergency department following a simple tonic-clonic seizure.
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- The primary motor cortex (M1) is essential for learning motor skills, and dopaminergic signaling from the ventral-tegmental area (VTA) plays a significant role in this process.
- Using techniques like calcium imaging and chemogenetic inhibition, researchers found that learning a dexterity task leads to a reorganization of M1 layer 2-3, changing how neurons connect and communicate while maintaining overall activity levels.
- Blocking VTA signals during learning halted these neural changes, highlighting the importance of dopaminergic input in developing outcome signaling and refined connectivity in M1, which is crucial for acquiring new motor skills.
Pancreatic ductal adenocarcinoma (PDAC) is a very challenging disease with a very poor prognosis. It is characterized by a dense desmoplastic stroma that hampers drug penetration and limits the effectiveness of conventional chemotherapy (CT). As an alternative, the combination of CT with hyperthermia (HT) has been proposed as an innovative treatment modality for PDAC.
View Article and Find Full Text PDFClimate-related disasters pose significant risks to mental health and well-being globally. Individuals from disaster-prone regions, such as Puerto Rico, are at even greater risk. The devastating effects of recurrent hurricanes, compounded with pre-existing structural disparities (e.
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