Motivations for obtaining advance provision of medication abortion in the United States: a qualitative study.

Background: Advance provision of medication abortion, or the prescription of mifepristone and misoprostol before pregnancy occurs, is an unexplored care model aimed at expanding abortion access. We examine motivations for obtaining advance provision from the online telemedicine service, Aid Access, which supports people in the United States.

Methods: Between May and November 2023, we conducted semi-structured, in-depth interviews with 39 people who obtained advance provision between January 2022 and April 2023.

Rete anomaly of the middle cerebral artery: case series of 13 patients from the Northeastern United States.

Background: Rete middle cerebral artery (MCA) is a rare anomaly of the intracranial circulation that mimics congenital Moyamoya disease (MMD). Similar to MMD, it is reported almost exclusively in East-Asian ethnicities. Here, we report 13 patients with rete MCA anomaly from a predominantly non-Asian background in the USA.

Bulk Condensation by an Active Interface.

We present experiments, supported by mechanically detailed simulations, establishing bulk condensation of a hard-bead fluid by a tiny population of orientable motile grains that self-assembles into a moving polarized monolayer. In a quasi-1D geometry two such layers, oppositely aligned, immobilize the condensed nonmotile component. We account for our observations through a continuum theory with a naturally nonreciprocal Cahn-Hilliard structure, whose predicted trends as a function of packing fraction are consistent with our observations.

Virtual Gene Panels Have a Superior Diagnostic Yield for Inherited Rare Diseases Relative to Static Panels.

Background: Exome- or genome-based panels-also known as slices or virtual panels-are now a popular approach that involves comprehensive genomic sequencing while restricting analysis to subsets of genes based on patients' phenotypes. This flexible strategy enables frequent gene updates based on novel disease associations as well as reflexing to analyzing other genes up to the whole exome or genome. With recent improvements addressing limitations associated with virtual panels, the advantages of this approach, relative to static custom-based panels, remain to be systematically characterized.