[Changes in phospholipid metabolism in subcellular structures of cardiac muscle of rabbits with experimental myocardial infarction].

Alteration in phospholipid turnover was studied in subcellular structures (nuclei, mitochondria, microsomes) of rabbit heart muscle within various postinfarctional periods (7, 14 and 21 days). The specificity of alterations in phospholipids as well as dissimilar direction of the alterations were observed in different subcellular structures of heart cells under conditions of myocardial infarction. Administration of etpenale contributed to increased synthesis of phospholipids (especially in mitochondrial fraction) with subsequent trend to normalization.

[Phospholipids and thromboplastins in various sections of the brain normally and in excitation states].

The level of the neutral and acid phospholipids and thromboplastic activity of various portions of the rabbit brain were studied under normal conditions and following adrenaline stimulation. The level of total phospholipids, neutral phospholipids, and the ratio of neutral to acid phospholipids, thromboplastic activity and its increase following incubation of homogenates of the brain tissue of normal and adrenaline-treated animals were found to be distributed in the following descending order: the medulla oblongata, cerebellum, cerebral hemispheres. Adrenaline decreased the thromboplastic activity and induced changes in the neutral and acid phospholipid levels.

Mechanism of cardiotonic action of monoethanolamine and its activity in experimental myocardial hypertrophy.

The authors investigated the cardiotonic effect of monoethanolamine (MEA) and its influence on experimental cardiac hypertrophy in albino rats. In isolated hearts, myocardial cells, and glycerinized fibres as well as in the whole organism of the animals, a distinct cardiotonic effect on MEA was observed, which was most marked in pathological states of the organism. In rats with experimental coarctation of the aorta, MEA dosed 10 mg/kg stimulated, and dosed 60 mg/kg, inhibited the development of myocardial hypertrophy, while the myocardial contractility remained sufficiently preserved.

[Relationship between thromboplastin activity in different brain structures and the quantitative interrelationships of functionally different groups of phospholipids in them].

The microsomal fraction of rabbit brain has the highest content of phospholipids and is completely devoid of polyglycerophospholipids. The decrease of the ratio of neutral to acid phospholipids is accompanied by a corresponding reduction of thromboplastic activity. Thromboplastic activity is high in the nuclear fraction of the medulla oblongata, cerebellum and cerebral hemispheres.