Inducing piezoelectric behavior in a copper iodide cubane cluster-based metal-organic framework linker engineering.

CuI cubane-type secondary building units are reticulated with a piperazine linker at room temperature to crystallize the metal-organic frameworks (MOFs) CuI(Pip) in a non-centrosymmetric 622 space group. For the first time, cubane cluster type MOF's strong piezoelectric nature has been studied by switching spectroscopy piezo force microscopy (SS-PFM) and piezo force microscopy (PFM) mapping of the crystal, with piezoelectric constant () ∼52.33 pm V, highlighting its potential for mechanical energy harvesting processes.

Defining Mechanistic Links Between the Non-Coding Variant rs17673553 in and Lupus Susceptibility.

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by widespread inflammation and autoantibody production. Its development and progression involve genetic, epigenetic, and environmental factors. Although genome-wide association studies (GWAS) have repeatedly identified a susceptibility signal at 16p13, its fine-scale source and its functional and mechanistic role in SLE remain unclear.

enhancement of CD8+ T cell activity using functionalized hydrogel encapsulating tonsil-derived lymphatic endothelial cells.

This study investigates a method for programming immune cells using a biomaterial-based system, providing an alternative to traditional cell manipulation techniques. It addresses the limitations of engineered adoptive T cell therapies, such as T cell exhaustion, by introducing a gelatin-hyaluronic acid (GH-GMA) hydrogel system. We characterized tonsil mesenchymal stem cells (TMSCs), lymphatic endothelial cells (T-LECs), stimulated T-CD8 T cells (STCs), and GH-GMA biomaterials.

A light-driven device for neuromorphic computing.

A unique optoelectronic synaptic device has been developed, leveraging the negative photoconductance property of a single-crystal material system called CsCoCl. This device exhibits a simultaneous volatile resistive switching response and sensitivity to optical stimuli, positioning CsCoCl as a promising candidate for optically enhanced neuromorphic applications.

Genetic and biochemical characterization of a radical SAM enzyme required for post-translational glutamine methylation of methyl-coenzyme M reductase.

Methyl-coenzyme M reductase (MCR), the key catalyst in the anoxic production and consumption of methane, contains an unusual 2-methylglutamine residue within its active site. data show that a B12-dependent radical SAM (rSAM) enzyme, designated MgmA, is responsible for this post-translational modification (PTM). Here, we show that two different MgmA homologs are able to methylate MCR when expressed in , an organism that does not normally possess this PTM.