Consideration of a Liquid Mutation-accumulation Experiment to Measure Mutation Rates by Successive Serial Dilution.

The mutation-accumulation (MA) experiment is a fixture of evolutionary biology, though its execution is laborious. MA experiments typically take between months and years to acquire sufficient mutations to measure DNA mutation rates and mutation spectra. MA experiments for many organisms rely on colony formation on agar plates and repetitive streaking, an environment which at first glance appears somewhat contrived, a poor imitation of actual environmental living conditions.

Evaporative coolers and wildfire smoke exposure: a climate justice issue in hot, dry regions.

Low-income families in dry regions, including in the Southwestern United States, frequently cool their homes with evaporative ("swamp") coolers (ECs). While inexpensive and energy efficient compared to central air conditioners, ECs pull unfiltered outdoor air into the home, creating a health hazard to occupants when wildfire smoke and heat events coincide. A community-engaged research project to reduce wildfire smoke in homes was conducted in California's San Joaquin Valley in homes of Spanish-speaking agricultural workers.

Diagnosis and Treatment of Gestational Diabetes Mellitus: A National Survey of Physician Practices.

We aimed to identify changes in United States practice patterns in gestational diabetes mellitus (GDM) diagnosis and treatment following publication of the 2008 Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study that supported transition toward a 2-hour oral glucose tolerance test. A total of 1,030 U.S.

Reirradiation Special Medical Physics Consultations: Lessons Learned from Nearly 3000 Courses of Treatment.

Introduction: Reirradiation (reRT) has become increasingly prevalent due to an aging population and advancements in cancer detection and treatment. However, the field is still lacking standardized dosimetric evaluation methods and reRT workflows, which leads to difficulty in correlating clinical outcomes with delivered dose. This study reports on the implementation and evolution of a standardized reRT workflow in the Department of Radiation Oncology at [redacted], describing insights gained from nearly 3000 external beam reirradiation courses delivered since 2017.