[Structural and Functional Remodeling of Vascular Wall in Persons With Family History of Hypertension].

Aim of investigation - to study parameters of structural and functional remodeling of vascular wall in persons with family history of hypertension (with burdened or positive hypertensive heredity). We examined 95 persons (aged 17 - 28 years) with family history of hypertension (positive hypertensive heredity) and divided them into 3 groups: group 1 - patients with arterial hypertension (AH), group 2 - patients with high normal blood pressure (BP), group 3 - persons with normal BP). Control (C) group comprised 24 subjects with normal BP without family history of AH.

Activity of lysosomal apparatus in rat myocardium during experimental coronary and noncoronary myocardial damage.

Cardiac and plasma activities of marker lysosomal enzymes were studied in Wistar rats with metabolic (epinephrine) and occlusion (ligation of coronary arteries) myocardial infarction. Activity of all examined lysosomal enzymes significantly increased in the myocardium and blood plasma starting from the first day after ligation of the coronary arteries and was accompanied by leukocytic infiltration of the myocardium. Enzyme activity gradually decreased to postoperation day 14.