Publications by authors named "S D Marchand"
Article Synopsis
- * In a case study, pneumonia caused by carbapenem-resistant Klebsiella pneumoniae showed cefiderocol resistance within just 32 days of treatment.
- * Genome sequencing revealed that the resistant bacteria carried mutations in siderophore receptor genes and were associated with the presence of certain β-lactamases, leading to increased resistance.
The rise of colistin-resistant Acinetobacter baumannii has severely limited treatment options for infections caused by this pathogen. While terpene alcohols and fatty acids have shown potential to enhance colistin's efficacy, but their high lipophilicity limits their clinical application. To address this, we developed water-dispersible lipid nanoparticles (LNPs) in two sizes (40 nm and 130 nm), loaded with these compounds to act as colistin adjuvants.
View Article and Find Full Text PDFObjectives: This study aimed to evaluate the efficacy of inhaled cationic antibiotics, including tobramycin (TOB) and colistin (CST), using an in vitro alginate bead model that simulates Pseudomonas aeruginosa lung biofilms.
Methods: Bioluminescent P. aeruginosa were encapsulated within alginate beads and dispersed in either Mueller-Hinton broth (MHB) or artificial sputum medium (ASM).
Objective: Attention deficit disorder with or without hyperactivity (ADHD) has negative consequences for children. The effectiveness of medical interventions and educational outcomes are strongly influenced by expectations, which can be modulated by nocebo effects. The aims of this study were to compare the nocebo effect on pain perception and attention in children with and without ADHD as well as to characterize the associations of the nocebo effect with personal variables, such as anxiety, sleep, and pain catastrophizing.
View Article and Find Full Text PDFArticle Synopsis
- Researchers have developed a method to analyze pain perception using a 2-min constant heat stimulation, moving beyond traditional group mean analysis due to significant individual variability in responses.
- New trajectory analysis techniques reveal distinct pain response profiles for participants, showing three unique trajectories: delayed peak pain, classic peak pain followed by a steady increase, and extreme responses with sharp fluctuations.
- The study found that socio-demographic factors, psychological aspects, and endocannabinoid levels, like anandamide, contribute to these diverse response patterns to pain.