Comparative evaluation of the pontic shield technique versus whole tooth extraction on labial crestal bone resorption using cone-beam computed tomography in the maxillary anterior region: A randomized controlled clinical trial.

Introduction: Following tooth extraction, there is comparatively more bone loss at the buccal aspect at 3 months of healing, which may result in 56% bone loss due to resorption of the bucco-facial ridge contour. In the socket shield technique, a tooth is planned for extraction in such a way that the tooth is sectioned in two halves, a palatal section is removed and the facial part is retained.

Materials And Methods: Twenty-six sites, i.

Functionalized quinolones and isoquinolones 1,2-difunctionalization of arynes: synthesis of antagonist agent AS2717638 and floxacin key intermediates.

Quinolones and isoquinolones are privileged scaffolds in synthetic/medicinal chemistry and drug discovery due to their unique chemical structures and intrinsic properties. Herein, we reveal a transition-metal-free approach for their synthesis from the reaction of dimethyl-2-((phenylamino)methylene)malonate with aryne precursors under mild conditions. The substrate scope is broad, accommodating a wide range of functional groups.

Regio- and Stereoselective Construction of 1,3,5-Triaroylcyclohexanes via KOBu-Mediated Cyclotrimerization of Aryl Vinyl Ketones.

Herein, we disclose a simple one-pot method for an efficient regio- and stereoselective synthesis of 1,3,5-triaroylcyclohexanes from aryl vinyl ketones using potassium -butoxide. The developed protocol allows the construction of various symmetrically substituted cyclohexanes in good to excellent yields. The major product also can be converted to the product (all equatorial) conveniently by acid catalysis.