Animal Models of Human Disease 2.0.

The use of animal models is crucial for advancing translational research by identifying effective treatment targets and strategies for clinical application in human disease [...

Promoting Family Involvement in the Management of Delirium in Intensive Care: Scoping Review.

: In recent years, family involvement in ICU patient care has become increasingly significant. Family involvement in delirium management, while desirable, can be difficult for loved ones. Therefore, every attempt should be made and interventions developed to promote and support the family in this process.

Generalized, sublethal damage-based mathematical approach for improved modeling of clonogenic survival curve flattening upon hyperthermia, radiotherapy, and beyond.

Mathematical modeling can offer valuable insights into the behavior of biological systems upon treatment. Different mathematical models (empirical, semi-empirical, and mechanistic) have been designed to predict the efficacy of either hyperthermia (HT), radiotherapy (RT), or their combination. However, mathematical approaches capable of modeling cell survival from shared general principles for both mono-treatments alone and their co-application are rare.

KMT2A degradation is observed in decitabine-responsive acute lymphoblastic leukemia cells.

Hypermethylation of tumor suppressor genes is a hallmark of leukemia. The hypomethylating agent decitabine covalently binds, and degrades DNA (cytosine-5)-methyltransferase 1 (DNMT1). Structural similarities within DNA-binding domains of DNMT1, and the leukemic driver histone-lysine N-methyltransferase 2A (KMT2A) suggest that decitabine might also affect the latter.

Gracilis flap and partial colpocleisis of Kahr for pelvic organ prolapse after anterior exenteration: A case report.

Anterior exenteration is a radical surgical option for treating locally advanced pelvic malignancies when alternative treatments are deemed ineffective or inappropriate. Due to its nature as an ablative treatment, interference with supportive structures of the pelvic floor can result in pelvic organ prolapse. A 70-year-old woman presented with prolapse after radical cystectomy and following two unsuccessful attempts at Le Fort colpocleisis, the second of which was further complicated by rupture of the vaginal cuff.