Publications by authors named "S D Janse van Rensburg"
South Africa was the most affected country in Africa by the coronavirus disease 2019 (COVID-19) pandemic, where over 4 million confirmed cases of COVID-19 and over 102,000 deaths have been recorded since 2019. Aside from clinical methods, artificial intelligence (AI)-based solutions such as machine learning (ML) models have been employed in treating COVID-19 cases. However, limited application of AI for COVID-19 in Africa has been reported in the literature.
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- Cerebral white matter lesions (WMLs) in people with multiple sclerosis (pwMS) are linked to the loss of myelin-producing cells, and current treatments aim to reduce these lesions and associated disabilities.
- A new genetic testing program identified risk factors for WML formation and suggested personalized lifestyle changes and nutrient optimization as possible preventive measures.
- A 10-year pilot study found that pwMS who followed these lifestyle interventions exhibited significantly smaller WML volumes compared to those who did not, highlighting the potential of dietary and lifestyle changes in managing MS, though further research is necessary.*
Background: COVID-19 vaccines offer different levels of immune protection but do not provide 100% protection. Vaccinated persons with pre-existing comorbidities may be at an increased risk of SARS-CoV-2 breakthrough infection or reinfection. The aim of this study is to identify the critical variables associated with a higher probability of SARS-CoV-2 breakthrough infection using machine learning.
View Article and Find Full Text PDFLipid metabolism may impact disability in people with multiple sclerosis (pwMS). Fifty-one pwMS entered an ultrasound and MRI study, of whom 19 had followed a pathology-supported genetic testing program for more than 10 years (pwMS-ON). Genetic variation, blood biochemistry, vascular blood flow velocities, diet and exercise were investigated.
View Article and Find Full Text PDFBackground: Although multiple sclerosis (MS) is an immune-related disorder, pharmaceutical interventions targeting the immune system do not stop or reverse disability progression; the major challenge for this condition. Studies show that disability progression in MS is associated with vascular comorbidity and brain volume loss, indicating that a multi-targeted approach is required to prevent debilitation. The aim of the present study was to examine the associations between vascular ultrasound, disability, biochemistry and lifestyle data in people with MS (pwMS).
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