Ultra-Brief Therapeutic Assessment with Three Chinese Adult Clients: A Case-Based Time-Series Pilot Study.

Therapeutic Assessment (TA) is a relatively new, short-term intervention that uses psychological tests to address clients' persistent problems in living. The core feature of TA is that assessors and clients work collaboratively in all the phases of the process, and psychological tests are used as "empathy magnifiers" to help assessors understand clients' "dilemmas of change" and promote positive change. An "ultra-brief" TA protocol involving an Initial Session, Test Administration and Extended Inquiry, and Summary/Discussion Session was undertaken with three adult clients in China.

Associations of Prostate Tumor Immune Landscape with Vigorous Physical Activity and Prostate Cancer Progression.

Background: Vigorous physical activity has been associated with lower risk of fatal prostate cancer. However, mechanisms contributing to this relationship are not understood.

Methods: We studied 117 men with prostate cancer in the University of North Carolina Cancer Survivorship Cohort (UNC CSC) who underwent radical prostatectomy and 101 radiation-treated patients with prostate cancer in FASTMAN.

ctDNA Dynamics and Mechanisms of Acquired Resistance in Patients Treated with Osimertinib with or without Bevacizumab from the Randomized Phase II ETOP-BOOSTER Trial.

Purpose: The ETOP 10-16 BOOSTER study was a randomized phase II trial of osimertinib and bevacizumab therapy versus osimertinib therapy in patients with an acquired EGFR T790M mutation. The mechanisms of acquired resistance to osimertinib and bevacizumab have not been described previously.

Experimental Design: Next-generation sequencing (Guardant360) was conducted in serial plasma samples.

Intratumoral vitamin D signaling and lethal prostate cancer.

High circulating vitamin D levels and supplementation may lower prostate cancer mortality. To probe for direct effects of vitamin D signaling in the primary tumor, we assessed how activation of intratumoral vitamin D signaling in prostate cancer is associated with lethal prostate cancer during long-term follow-up. Among 404 participants with primary prostate cancer in the Health Professionals Follow-up Study and the Physicians' Health Study, we defined a gene score of expected activated intratumoral vitamin D signaling consisting of transcriptionally upregulated (CYP27A1, CYP2R1, RXRA, RXRB, and VDR) and downregulated genes (CYP24A1 and DHCR7).