Crizotinib: aseptic abscesses in multiple organs during treatment of EML4-ALK-positive NSCLC.

Purpose: We report a novel side effect of Crizotinib, an oral ALK inhibitor used in the treatment of non-small cell lung cancer (NSCLC) with activating rearrangement of EML4-ALK. It expands the known spectrum of complications of Crizotinib.

Methods: Clinical case report.

Multi-scale analysis of segmental outflow patterns in human trabecular meshwork with changing intraocular pressure.

Purpose: Aqueous humor filtration in the trabecular meshwork is believed to be non-uniform or "segmental" such that only a fraction of trabecular meshwork is filtration-active at any given instant. The goal was to quantify the filtration-active fraction of human trabecular meshwork and to determine how filtration patterns change with outflow facility and intraocular pressure (IOP).

Methods: Six pair of enucleated human eyes were perfused with fluorescent tracer microspheres (0.

Morphometric analysis of aqueous humor outflow structures with spectral-domain optical coherence tomography.

Purpose: To describe morphometric details of the human aqueous humor (AH) outflow microvasculature visualized with 360-degree virtual castings during active AH outflow in cadaver eyes and to compare these structures with corrosion casting studies.

Methods: The conventional AH outflow pathways of donor eyes (n = 7) and eyes in vivo (n = 3) were imaged with spectral-domain optical coherence tomography (SD-OCT) and wide-bandwidth superluminescent diode array during active AH outflow. Digital image contrast was adjusted to isolate AH microvasculature, and images were viewed in a 3D viewer.

Plasma and urine disposition and dose proportionality of ceftiofur and metabolites in dogs after subcutaneous administration of ceftiofur sodium.

Nine male dogs (10.3-13.5 kg body weight) were randomly assigned to three groups of three dogs each and administered ceftiofur sodium subcutaneously as a single dose of 0.

Abdominal manifestations of sarcoidosis in CT studies.

Objective: The purpose of this study is to demonstrate the spectrum of abdominal CT findings in patients with tissue proved sarcoidosis, estimate their prevalence, and correlate abdominal findings with stage of thoracic disease.

Materials And Methods: Between 1987 and 1993, 140 patients with tissue proved sarcoidosis underwent abdominal or chest CT at our institution. After exclusions, 49 patients remained.