Publications by authors named "S D Crockett"
Importance: Colorectal cancer (CRC) screening is effective but remains underused in federally qualified health centers (FQHCs).
Objective: To assess the effectiveness of a centralized CRC screening outreach intervention involving mailed fecal immunochemical testing (FIT) outreach and patient navigation to colonoscopy after abnormal results of FIT.
Design, Setting, And Participants: A pragmatic randomized clinical trial was conducted, using intention-to-treat analysis.
Interferon (IFN) induced activities are critical, early determinants of immune responses and infection outcomes. A key facet of IFN responses is the upregulation of hundreds of mRNAs termed interferon-stimulated genes (ISGs) that activate intrinsic and cell-mediated defenses. While primary interferon signaling is well-delineated, other layers of regulation are less explored but implied by aberrant ISG expression signatures in many diseases in the absence of infection.
View Article and Find Full Text PDFPractical steps to green your endoscopy unit: appropriate management of endoscopic waste.
Gastrointest Endosc
October 2024
Article Synopsis
- * Researchers identified three subclasses of ISGs in uninfected human tissues and found that the cellular metabolic environment (either aerobic glycolysis or oxidative phosphorylation) significantly affects ISG expression, particularly in response to different IFNs.
- * The study revealed that while the metabolic conditions altered the expression of certain ISG proteins, like IRF1 and IFITM3, the levels of viral replication from poxvirus (vaccinia) varied based on glucose or galactose environments