Publications by authors named "S D Brookman-May"
Modification and Validation of the System Causability Scale Using AI-Based Therapeutic Recommendations for Urological Cancer Patients: A Basis for the Development of a Prospective Comparative Study.
Emily Rinderknecht Dominik von Winning Anton Kravchuk Christof Schäfer Marco J Schnabel Sabine D Brookman-May
Curr Oncol
November 2024
Article Synopsis
- The study explores the use of Large Language Models (LLMs) to enhance decision-making in urological cancer treatment, aiming to compare their recommendations with those of traditional tumor boards.
- It validates two scoring scales, the System Causability Scale (SCS) and its modified version (mSCS), showing they have strong reliability and internal consistency for future trials.
- The upcoming CONCORDIA trial will formally test LLM recommendations against multidisciplinary tumor board recommendations across 110 urological cancer scenarios.
What Is This Summary About?: This is a summary of a paper that describes the results of the SPARTAN and TITAN studies, which looked at whether a treatment called apalutamide can help treat individuals with advanced prostate cancer.The SPARTAN study included 1207 participants with nonmetastatic castration-resistant prostate cancer (or nmCRPC). The TITAN study included 1052 participants with metastatic castration-sensitive prostate cancer (or mCSPC).
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the effectiveness and safety of apalutamide combined with goserelin for treating androgen receptor-positive unresectable or metastatic salivary gland carcinoma.
- A total of 31 patients were enrolled, but only 25% of the first 24 patients responded to the treatment, which did not meet the expected effectiveness criteria; however, the clinical benefit rate was 50%.
- The treatment demonstrated potential benefits in a subgroup of patients with high AR positivity (≥70%) and reported side effects were in line with what’s typically observed in prostate cancer treatments.