Publications by authors named "S D Bos"
Background: Antimicrobial use data from inpatients in northern Canada suitable to inform stewardship programs are limited.
Objective: As a special project of the Canadian Nosocomial Infection Surveillance Program, to describe antimicrobial use for inpatients in northern Canadian acute care hospitals.
Methods: Participating acute care hospitals serving adult or mixed adult and pediatric populations in northern Canada submitted annual data on the use of all systemic antimicrobials from 2019 to 2021.
Objectives: SARS-CoV-2 viral load could be an important parameter for transmission potential. Here, we use RT-qPCR cycle threshold (Ct) values as a proxy for viral load. We assess the effect of COVID-19 vaccination and prior infection status on Ct value, while accounting for the virus variant.
View Article and Find Full Text PDFHigh-dimensional tissue profiling of immune cell responses in chronic lung allograft dysfunction.
J Heart Lung Transplant
November 2024
Article Synopsis
- The study investigates the immune mechanisms behind chronic lung allograft dysfunction (CLAD), which hampers long-term survival after lung transplants, using advanced tissue imaging techniques.
- Researchers analyzed lung tissue from 23 transplant recipients, identifying differences in immune cell populations associated with CLAD versus non-CLAD conditions.
- Key findings show that specific immune cells, like cytotoxic T cells and γδ T cells, expand in CLAD, highlighting unique characteristics in different CLAD phenotypes and offering new insights into how fibrosis progresses in these conditions.*
Background: Dengue is the most prevalent mosquito-borne viral disease and a major public health problem worldwide. Most primary infections with the four dengue virus serotypes (DENV1-4) are inapparent; nonetheless, whether the distribution of symptomatic versus inapparent infections by serotype varies remains unknown. Here, we present (1) the evaluation of a DENV1-4 envelope domain III multiplex microsphere-based assay (EDIII-MMBA) to serotype inapparent primary infections and (2) its application leveraging 17 years of prospective sample collection from the Nicaraguan Pediatric Dengue Cohort Study (PDCS).
View Article and Find Full Text PDFPurpose: Many consider white matter hyperintensities (WMHs) to be important imaging findings in neuroborreliosis. However, evidence regarding association with WMHs is of low quality. The objective was to investigate WMHs in neuroborreliosis visually and quantitatively.
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