Publications by authors named "S D Billings"
Aims: Ossifying fibromyxoid tumour is a rare mesenchymal neoplasm predominantly affecting adults characterised by a multinodular growth pattern and the presence of a fibrous pseudocapsule with areas of ossification. Prompted by the recognition of a non-ossifying ossifying fibromyxoid tumour with lipomatous differentiation which caused diagnostic difficulty, we sought to further explore cases of ossifying fibromyxoid tumour with non-osseous heterologous elements.
Methods And Results: A search of our institutional and consultation archives revealed three additional cases that demonstrated lipomatous components and two cases with cartilaginous differentiation.
Article Synopsis
- - The study focused on 44 cases of epithelioid myxofibrosarcoma (eMFS), a rare and aggressive cancer variant, examining factors like morphologic structure and cancer grading, revealing that the majority displayed diffuse epithelioid characteristics and high FNCLCC grades.
- - Among the patients, mostly older adults with a higher incidence in males, local recurrence and metastasis were common; specifically, 10 out of 22 monitored patients developed metastases, typically to regional lymph nodes, regardless of tumor grade.
- - An interesting note is that some cases initially diagnosed as eMFS shared genetic mutations typically seen in other UV-driven cancers, suggesting possible misdiagnosis and the need for careful evaluation
Article Synopsis
- Superficial malignant peripheral nerve sheath tumors (SF-MPNSTs) are rare cancers that share some features with spindle cell melanomas and desmoplastic melanomas, but their biological characteristics remain poorly understood.* -
- A study comparing SF-MPNST to other tumor types through whole-exome and RNA sequencing found that SF-MPNST had an intermediate tumor mutational burden and distinct gene expression patterns, indicating differences among these cancer types.* -
- Immunohistochemical analysis revealed notable differences in markers like H3K27me3 and PRAME between SF-MPNST and other cancers, suggesting potential for new diagnostic markers and insights into tumor behavior.*
Article Synopsis
- * Recent cases of the tumor were reported in five patients (from ages 8 to 69) who presented with solitary masses on various body parts, with all undergoing surgical excision and showing no disease upon follow-up.
- * The study reveals unique morphological and molecular characteristics of these tumors and suggests rebranding the tumor as "superficial neurocristic FET::ETS fusion tumor" to better reflect its distinct nature.