Incident adverse drug reactions in geriatric inpatients: a multicentred observational study.

Background: Adverse drug reactions (ADRs) are common in older adults and frequently have serious clinical and economic consequences. This study was conducted as a feasibility study for a randomized control trial (RCT) that will investigate the efficacy of a software engine to optimize medications and reduce incident (in-hospital) ADRs. This study's objectives were to (i) establish current incident ADR rates across the six sites participating in the forthcoming RCT and (ii) assess whether incident ADRs are predictable.

Safety climate dimensions as predictors for risk behavior.

This study examines the interactive relationship between three dimensions of safety climate (management commitment to safety, priority of safety, and pressure for production), and their impact on risk behavior reported by employees. The sample consisted of 623 employees from a chemical manufacturing organization in South Africa. Hierarchical regression analyses were carried out to test the direct effects and the interaction effect of the three safety climate dimensions on risk behavior.

Policy, principle, and practice in industrial pollution control: views from the regulatory interface.

There has been much criticism of the system for the control of industrial pollution, but not much is known about the views of the regulators and the industry. The objective of this study was to explore the attitudes at this regulatory interface towards the current and proposed regulatory system and make recommendations for improvements. The methodology involved a questionnaire survey sent to over 700 key personnel.

Vasopressin in the treatment of milrinone-induced hypotension in severe heart failure.

The use of phosphodiesterase inhibitors such as milrinone in the treatment of severe heart failure is frequently restricted because they cause vasodilation and hypotension. In patients with decompensated heart failure with hypotension after treatment with milrinone, low doses of vasopressin restored blood pressure without inhibiting the inotropic effect of milrinone.

Vasopressin as an alternative to norepinephrine in the treatment of milrinone-induced hypotension.

Objective: To determine whether vasopressin could be effective in treating the hypotension associated with phosphodiesterase III inhibition. Phosphodiesterase III inhibitors are cardiotonic agents that increase myocardial contractility and decrease vascular smooth muscle tone. The vasodilatory effect can be profound, and the resulting hypotension frequently requires the administration of catecholamine pressors.