Dysbiosis: An Indicator of COVID-19 Severity in Critically Ill Patients.

Here, we examined the dynamics of the gut and respiratory microbiomes in severe COVID-19 patients in need of mechanical ventilation in the intensive care unit (ICU). We recruited 85 critically ill patients (53 with COVID-19 and 32 without COVID-19) and 17 healthy controls (HCs) and monitored them for up to 4 weeks. We analyzed the bacterial and fungal taxonomic profiles and loads of 232 gut and respiratory samples and we measured the blood levels of Interleukin 6, IgG, and IgM in COVID-19 patients.

Social Vulnerability and Safe Building Recertification Violations in Miami, Florida, 2013-2018.

To determine whether an association exists between Social Vulnerability Index (SVI) scores and 40-year recertification violation within the City of Miami, Florida. A cross-sectional, observational secondary data analysis of social and housing vulnerability, including the Centers for Disease Control and Prevention's SVI overall themes, estimated median year a housing unit was built, and 40-year recertification code violation data. We conducted the study using data sets from 2013 to 2018 at the census tract level in response to the collapse of Champlain Tower South in Surfside, Florida.

Founder mutation in myosin-binding protein C with an early onset and a high penetrance in males.

Objective: One of the challenges in hypertrophic cardiomyopathy (HCM) is to determine the pathogenicity of genetic variants and to establish genotype/phenotype correlations. This study aimed to: (1) demonstrate that c.2149-1G>A is a founder pathogenic variant, (2) describe the phenotype and clinical characteristics of mutation carriers and (3) compare these patients with those with the most frequent pathogenic HCM variants: p.