Publications by authors named "S Croci"
Background: Vascular inflammation persists in temporal artery biopsy (TAB) of giant cell arteritis (GCA) patients even after prolonged glucocorticoid (GC) therapy. We aimed to evaluate the histological impact of adding tocilizumab (TCZ) to GCs.
Methods: We enrolled all consecutive GCA patients with an inflammed TAB at diagnosis who were treated with TCZ and GCs for ≥6 months and followed from December 2017 to December 2023.
CDKL5 deficiency disorder (CDD) is a rare neurodevelopmental syndrome caused by mutations in the X-linked CDKL5 gene. Hundreds of pathogenic variants have been described, associated with a significant phenotypic heterogeneity observed among patients. To date, different knockout mouse models have been generated.
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- - The study aimed to identify genes that are differently expressed in temporal artery biopsies (TABs) from patients with giant cell arteritis (GCA) showing varied inflammation patterns, specifically transmural inflammation (TMI) and inflammation limited to adventitia (ILA), compared to non-GCA controls.
- - An analysis of 770 immune-related genes revealed that TABs with TMI had significantly more gene expression changes (256 upregulated and 31 downregulated) versus normal TABs, while TABs with ILA mostly resembled normal samples with fewer significant changes.
- - The findings highlighted that TMI TABs exhibit a unique gene expression profile that contributes to understanding GCA's underlying mechanisms, as opposed to TABs with ILA
Objectives: To assess the maintenance of efficacy of one year of tocilizumab (TCZ) monotherapy after its discontinuation in large vessel-GCA (LV-GCA).
Methods: 17 patients with active LV-GCA were previously treated with 3 boluses of intravenous methylprednisone and weekly subcutaneous TCZ in monotherapy for 52 weeks. Patients in relapse-free clinical remission at week 52 discontinued TCZ and entered part two, which was a 26-week observational follow-up period.
Article Synopsis
- Giant cell arteritis (GCA) is a disease that mostly affects people over 50 and can cause serious health problems like loss of vision or strokes.
- Current ways to diagnose GCA, like taking a biopsy or using ultrasound, have some limitations, and scientists are looking for new methods to help.
- This study discovered specific antibodies that could help diagnose GCA more easily, which might improve how doctors identify and treat this disease in the future.