Publications by authors named "S Cro"
Background: In the United Kingdom, it is estimated that 5,000 patients sustain eye injuries or ocular trauma requiring hospital admission annually, of which 250 patients will be permanently blinded. This study explores the cost-effectiveness of Adjunctive Steroid Combination in Ocular Trauma (ASCOT) given during surgery versus standard treatment in vitreoretinal surgery in patients with open globe trauma.
Methods: This economic evaluation was embedded alongside the ASCOT RCT (ClinicalTrials.
Vaccines are crucial for protecting health globally; however, their widespread use relies on rigorous clinical development programmes. This includes Phase 3 randomised controlled trials (RCTs) to confirm their safety, immunogenicity, and efficacy. Traditionally, such trials used fixed designs with predetermined assumptions, lacking the flexibility to change during the trial or stop early due to overwhelming evidence of either efficacy or futility.
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- Eczema is a major global skin condition that is often treated with topical anti-inflammatory treatments, but there is uncertainty about their effectiveness and safety.* -
- A network meta-analysis was conducted to compare various topical treatments based on data from 291 trials involving over 45,000 participants, primarily from high-income countries.* -
- The analysis found that potent topical steroids and tacrolimus 0.1% were among the most effective treatments; however, many trials exhibited high risk of bias, particularly concerning selective reporting.*
Introduction: Digital mental health interventions (DMHIs) overcome traditional barriers enabling wider access to mental health support and allowing individuals to manage their treatment. How individuals engage with DMHIs impacts the intervention effect. This review determined whether the impact of user engagement was assessed in the intervention effect in Randomised Controlled Trials (RCTs) evaluating DMHIs targeting common mental disorders (CMDs).
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