Inhibition of diacylglycerol lipase α induced blood-brain barrier breach in female Sprague-Dawley rats.

The endocannabinoid system's significance in maintaining blood-brain barrier (BBB) integrity under physiological and pathological conditions is suggested by several reports, but the underlying molecular mechanisms are not well understood. In this paper, we investigated the effects of depletion of 2-arachidonoylglycerol (2-AG), one of the main endocannabinoids in the central nervous system, on BBB integrity using pharmacological tools. Female Sprague-Dawley rats were injected with the diacylglycerol lipase α (DAGLα) inhibitor LEI-106 (40 mg/kg, i.

Risk-Taking Behaviors of Young Children: The Role of Children's and Parents' Socioemotional and Cognitive Control Systems.

To prevent young children's injuries, studies have considered both child (e.g., temperament, age, sex) and parent factors (e.

Mental disorder diagnoses and symptoms and functional impairment in school-age children in the care of child protective services.

Background: About 50 % of children in the care of child protective services present at least one mental disorder, but few studies have looked at whether there are differences in mental disorders or symptoms between children placed in out-of-home care (foster care and residential care) and their community peers.

Objective: This study documents the mental disorder diagnoses and symptoms among children in out-of-home care and their associations with children functional impairment. It also compares out-of-home care children with those from the community.

Identifying practices of information transfer between the hospital and primary care for older adults: a scoping review protocol.

Introduction: Transition of care from hospital to primary care has been recognised globally as a high-risk scenario for older patients' safety by the WHO. Indeed, sub-optimal care transitions are associated with increased mortality, morbidity and adverse events.Improving communication through timely and accurate clinical information transfer has been identified as a key component of optimal care transitions.

The effect of trunk position and pain location on lumbar extensor muscle recruitment strategies.

The aim of this study was to investigate the effect of trunk position and experimental lumbar pain location on lumbar extensor muscle recruitment strategies. Nineteen healthy participants (10 men and 9 women), aged 25.3 ± 4.