Publications by authors named "S Courbage"

Background: The determinants of early-onset obesity (< 6 years) are not completely elucidated, however eating behavior has a central role. To date no study has explored eating behavior in children with severe, early-onset obesity. Self-administered questionnaire data from these children were examined to evaluate eating behavior and the etiology of early-onset obesity.

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Article Synopsis
  • The study investigates the role of heterozygous variants in genes related to severe obesity, specifically focusing on LEP, LEPR, POMC, and PCSK1.
  • It analyzed data from 1486 individuals with severe obesity, finding a higher frequency of heterozygous variants compared to homozygous ones, and noted differences in BMI and obesity onset between these groups.
  • The findings suggest that heterozygous variants can lead to significant obesity-related phenotypes and highlight the need for targeted genetic analysis in cases of severe early-onset obesity for potential therapeutic strategies.
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Long-term outcomes in children undergoing intestinal transplantation remain unclear. Seventy-one children underwent intestinal transplantation in our center from 1989 to 2007. We report on 10-year posttransplant outcomes with (group 1, n = 26) and without (group 2, n = 9) a functional graft.

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Eosinophilic esophagitis (EoE) is a multifactorial esophageal inflammation, with a genetic predisposition, which combines a deficient esophageal mucosal barrier, an abnormal immune reaction to environmental allergens mediated by Th2 interleukins, immediate esophageal lesions and dysmotility, with secondary remodeling and fibrosis. Symptoms include reflux, abdominal pain, and food impaction, with a variation according to age. Fibroscopy shows major and minor endoscopic and histologic criteria, with a mucosal count≥15 eosinophils/high power field (Eo/hpf).

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Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis, is a rare cause of lymphadenopathy in children. This benign disease can mimic lymphoma and misleads doctors. It was first described in Asia, where it occurred especially in young women.

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