Publications by authors named "S Cosma"
Background: Pregnancy has been identified as a risk factor for severe COVID-19, leading to maternal and neonatal complications. The safety and effects of the SARS-CoV-2 vaccination during pregnancy, particularly on placental function and oxidative stress (OxS), remain underexplored. We investigated the impact of vaccination on third-trimester placental antioxidant defense markers.
View Article and Find Full Text PDFThe enzyme topoisomerase II alpha (TOP2A) plays a critical role in DNA replication and cell proliferation, making it a promising target for cancer therapy. In epithelial ovarian cancer (EOC), TOP2A overexpression is associated with poor prognosis and resistance to conventional treatments. This review explores the biological functions of TOP2A in EOC and discusses its potential as a therapeutic target.
View Article and Find Full Text PDFArticle Synopsis
- Advanced therapies hold great potential for medical advancements, but their funding is significantly challenged by various factors that impede their market success, even after approval.
- This study conducts a thorough review of 174 articles from 2001 to 2023 to identify these funding barriers and proposes future research directions to address the financial challenges encountered by these therapies.
- It emphasizes the need for a multidisciplinary approach to tackle these issues collectively and advocates for innovative financial models and public-private partnerships to enhance the sustainability and social impact of advanced therapies.
Objective: Missing occult para-aortic lymph node metastasis is one of the primary concerns of sentinel lymph node biopsy in endometrial cancer. Our study aimed to evaluate the relationship between intrauterine cancer site and isolated para-aortic lymph node metastasis to tailor treatment and reduce the false negative rate of the sentinel lymph node procedure.
Methods: A retrospective, multicenter, case control study was performed in four international centers.