Publications by authors named "S Cortellino"
Neoplastic transformation reprograms tumor and surrounding host cell metabolism, increasing nutrient consumption and depletion in the tumor microenvironment. Tumors uptake nutrients from neighboring normal tissues or the bloodstream to meet energy and anabolic demands. Tumor-induced chronic inflammation, a high-energy process, also consumes nutrients to sustain its dysfunctional activities.
View Article and Find Full Text PDFThe biophysical and biomechanical properties of the extracellular matrix (ECM) are crucial in the processes of cell differentiation and proliferation. However, it is unclear to what extent tumor cells are influenced by biomechanical and biophysical changes of the surrounding microenvironment and how this response varies between different tumor forms, and over the course of tumor progression. The entire ensemble of genes encoding the ECM associated proteins is called matrisome.
View Article and Find Full Text PDFInflammation is a key contributor to both the initiation and progression of tumors, and it can be triggered by genetic instability within tumors, as well as by lifestyle and dietary factors. The inflammatory response plays a critical role in the genetic and epigenetic reprogramming of tumor cells, as well as in the cells that comprise the tumor microenvironment. Cells in the microenvironment acquire a phenotype that promotes immune evasion, progression, and metastasis.
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- Immune checkpoint inhibitors can cause serious side effects like autoimmune disorders and heart damage.
- Periodic Fasting Mimicking Diet (FMD) shows promise in enhancing cancer therapies, particularly when combined with anti-OX40/anti-PD-L1, resulting in better melanoma growth delays in mice.
- FMD not only boosts the effectiveness of immunotherapy but also helps prevent or reverse heart damage linked to these treatments by reducing inflammation and oxidative stress.
Article Synopsis
- The remodeling of cancer cell metabolism alters the tumor microenvironment by affecting nutrient levels and releasing substances that recruit immunosuppressive immune cells.
- Dietary interventions like amino acid restriction and fasting mimicking diets can help counteract this immunosuppressive environment by influencing hormone and growth factor release, reducing proinflammatory cytokines, and remodeling surrounding tumor structures.
- Recent research highlights the potential of these dietary approaches in enhancing cancer therapy through their effects on immunometabolism and tumor immune responses.