Optimizing Wound Culture Ordering in Electronic Health Records: A Case Report.

Background: At a large quaternary health system, tissue specimens were frequently sent to the microbiology laboratory with an incorrect wound culture order meant for swab specimens due to poor electronic health record menu design. Wound cultures were also requested in chronic wound cases with a low index of suspicion for acute infection.

Objective: To present a case report on specific changes to the design of the electronic test menu that resulted in higher numbers of appropriate ordering practices.

Integrated Whole Genome and Transcriptome Sequencing as a Framework for Pediatric and Adolescent AML Diagnosis and Risk Assessment.

Pediatric acute myeloid leukemia (AML) exhibits distinct genetic characteristics, including unique driver alterations and mutations with prognostic and therapeutic significance. Emerging rare, recurrent genetic abnormalities and their associations with outcomes emphasize the need for high-throughput molecular diagnostic tools. Whole genome sequencing (WGS) reliably detects key AML biomarkers such as structural variants, mutations, and copy number alterations.

Substantial Mercury Releases and Local Deposition from Permafrost Peatland Wildfires in Southwestern Alaska.

Increasing wildfire activity at high northern latitudes has the potential to mobilize large amounts of terrestrial mercury (Hg). However, understanding implications for Hg cycling and ecosystems is hindered by sparse research on peatland wildfire Hg emissions. In this study, we used measurements of soil organic carbon (SOC) and Hg, burn depth, and environmental indices derived from satellite remote sensing to develop machine learning models for predicting Hg emissions from major wildfires in the permafrost peatland of the Yukon-Kuskokwim Delta (YKD) in southwestern Alaska.