Publications by authors named "S Cooper Ben"
Chronic dacryocystitis (CD) can result in severe complications and vision impairment due to ongoing microbial infections and persistent tearing. Tear fluid, which contains essential components vital for maintaining ocular surface health, has been investigated for its potential in the noninvasive identification of ocular biomarkers through metabolomics analysis. In this study, we employed UHPLC-MS/MS to analyze the tear metabolome of CD patients.
View Article and Find Full Text PDFAngular streaking technique employs a close-to-circularly polarized laser pulse to build a mapping between the instant of maximum ionization and the most probable emission angle in the photoelectron momentum distribution, thereby enabling the probe of laser-induced electron dynamics in atoms and molecules with attosecond temporal resolution. Here, through the jointed experimental observations and improved Coulomb-corrected strong-field approximation statistical simulations, we identify that electrons emitted at different initial ionization times converge to the most probable emission angle due to the previously-unexpected Coulomb focusing triggered by the nonadiabatic laser-induced electron tunneling. We reveal that the Coulomb focusing induces the observed nonintuitive energy-dependent trend in the angular streaking measurements on the nonadiabatic tunneling, and that tunneling dynamics under the classically forbidden barrier can leave fingerprints on the resulting signals.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between exposure to persistent organic pollutants (POPs), particularly PCB153, and the risk of colorectal cancer in a Chinese population.
- It employs gas chromatography-tandem mass spectrometry to measure plasma levels of 24 POPs, finding that colorectal cancer patients have higher levels of these pollutants.
- The research identifies a genetic variant (rs67734009) that is linked to lower colorectal cancer risk and PCB153 levels, highlighting the genetic and epigenetic mechanisms involved in how POPs may influence cancer risk.
Purpose: This study aims to explore the metabolic signature of aging retina and identify the potential metabolic biomarkers for the diagnosis of retinal aging.
Methods: Retinal samples were collected from both young (two months) and aging (14 months) mice to conduct an unbiased metabolic profiling. Liquid chromatography-tandem mass spectrometry analysis was conducted to screen for the metabolic biomarkers and altered signaling pathways associated with retinal aging.
Article Synopsis
- The study investigates the role of PIWI-interacting RNAs (piRNAs) and their genetic variants in the risk and progression of prostate cancer (PCa) using data from over 85,000 PCa cases and 166,000 controls.
- A specific genetic variant, rs17201241, is linked to increased expression of PROPER, a piRNA associated with higher risk and severity of PCa, which works by affecting mRNA interactions and promoting cancer progression through the p38 MAPK signaling pathway.
- Targeting PROPER has shown potential in suppressing tumor growth in experimental models, suggesting it could be a valuable target for new PCa treatments.