Publications by authors named "S Colomb"
Article Synopsis
- Adult brain explants (OPABs) can be cultured to study synaptic plasticity, which is important for understanding brain functions.
- The research involved stimulating these explants on a 3D microelectrode array to examine changes in neuronal connections over several days.
- Results showed that while immediate synaptic changes didn't occur, after a few days, significant responses were noted, indicating that these brain tissues retain the ability for synaptic modulation, especially influenced by dopamine.
Article Synopsis
- - SARS-CoV-2 infection can cause both immediate and long-lasting neurological issues, complicating the understanding of the virus's impact on the brain after COVID-19.
- - Research using brain models and samples shows that while SARS-CoV-2 can infect neural cells, the extent is low, but it can lead to abnormal changes in synapses and electrical activity in the brain.
- - The study found that treating brain organoids with a specific compound could help restore normal brain activity and reduce the negative effects caused by the virus at synapses, highlighting potential avenues for understanding and treating COVID-19-related brain complications.
Viral neuroinfections represent a major health burden for which the development of antivirals is needed. Antiviral compounds that target the consequences of a brain infection (symptomatic treatment) rather than the cause (direct-acting antivirals) constitute a promising mitigation strategy that requires to be investigated in relevant models. However, physiological surrogates mimicking an adult human cortex are lacking, limiting our understanding of the mechanisms associated with viro-induced neurological disorders.
View Article and Find Full Text PDFBackground: The determination of skin wound vitality based on tissue sections is a challenge for the forensic pathologist. Histology is still the gold standard, despite its low sensitivity. Immunohistochemistry could allow to obtain a higher sensitivity.
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