Publications by authors named "S Collis"
SUMOylation, the covalent attachment of the small ubiquitin-like modifier (SUMO) to target proteins, and its reversal, deSUMOylation by SUMO proteases like Sentrin-specific proteases (SENPs), are crucial for initiating cellular responses to hypoxia. However, their roles in subsequent adaptation processes to hypoxia such as mitochondrial autophagy (mitophagy) remain unexplored. Here, we show that general SUMOylation, particularly SUMO2/3 modification, suppresses mitophagy under both normoxia and hypoxia.
View Article and Find Full Text PDFA retrospective study of the injury patterns seen in fatal falls downstairs.
J Forensic Leg Med
November 2024
Article Synopsis
- Fatal falls involving stairs are common in older adults and those with certain health conditions, but often the role of a third party is hard to determine based solely on medical examination.
- The study aimed to analyze cases of fatal stair falls over a decade to distinguish between those classified as accidental and those deemed undetermined.
- Findings revealed that undetermined falls had more severe injuries, like craniofacial fractures and intracranial damage, indicating a need for in-depth investigations by coroners beyond just the medical evidence.
Article Synopsis
- Femicide is a severe form of violence against women that is poorly defined and underreported in Ireland, and it's becoming a growing concern as statistics indicate that many women experience Intimate Partner Violence (IPV).
- This study aimed to examine femicide cases in Ireland over the past 12 years, revealing an increase in femicide rates, with domestic homicides being the most prevalent.
- Results showed that a significant number of femicides were committed by intimate partners, often involved severe violence, and the lack of official data complicates understanding the true extent of the issue.
Glioblastoma is an aggressive, incurable brain cancer with poor five-year survival rates of around 13% despite multimodal treatment with surgery, DNA-damaging chemoradiotherapy and the recent addition of Tumour Treating Fields (TTFields). As such, there is an urgent need to improve our current understanding of cellular responses to TTFields using more clinically and surgically relevant models, which reflect the profound spatial heterogeneity within glioblastoma, and leverage these biological insights to inform the rational design of more effective therapeutic strategies incorporating TTFields. We have recently reported the use of preclinical TTFields using the inovitro system within 2D glioma stem-like cell (GSC) models and demonstrated significant cytotoxicity enhancement when co-applied with a range of therapeutically approved and preclinical DNA damage response inhibitors (DDRi) and chemoradiotherapy.
View Article and Find Full Text PDFBackground: Glioblastomas have highly infiltrative growth patterns that contribute to recurrence and poor survival. Despite infiltration being a critical therapeutic target, no clinically useful therapies exist that counter glioblastoma invasion. Here, we report that inhibition of ataxia telangiectasia and Rad 3 related kinase (ATR) reduces invasion of glioblastoma cells through dysregulation of cytoskeletal networks and subsequent integrin trafficking.
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