Publications by authors named "S Cohn"

Multidisciplinary team meetings are part of the everyday working life of palliative care staff. Based on ethnographic material from community and hospital palliative care teams in England, this article examines these meetings as dynamic routines. Although intended to have a prescribed format to review deaths and collect standardised information to monitor service performance, in practice, the content and conduct of the meetings were fluid, reflecting how this structure did not always match the concerns held by the team.

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A deep learning model using attention-based multiple instance learning (aMIL) and self-supervised learning (SSL) was developed to perform pathologic classification of neuroblastic tumors and assess MYCN-amplification status using H&E-stained whole slide images from the largest reported cohort to date. The model showed promising performance in identifying diagnostic category, grade, mitosis-karyorrhexis index (MKI), and MYCN-amplification with validation on an external test dataset, suggesting potential for AI-assisted neuroblastoma classification.

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Article Synopsis
  • Tumor invasion of the spinal canal occurs in about 15% of newly diagnosed neuroblastoma patients, prompting a need for effective treatment strategies that optimize survival while minimizing long-term effects.
  • A study of 92 intermediate-risk neuroblastoma patients with intraspinal tumors revealed that nearly half were symptomatic at diagnosis, but most of them experienced complete resolution of symptoms following treatment, regardless of the initial severity or duration of their deficits.
  • The findings suggest that while prompt diagnosis and chemotherapy are crucial, surgical options like laminectomy may not significantly improve motor symptoms, indicating that surgery should be reserved for cases with rapid worsening neurologic conditions.
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Irritable bowel syndrome (IBS) is a common and potentially modifiable contributor to excess disability, morbidity, and poor quality of life. Clinical trials of medications for IBS have largely been in younger adults. Yet, a growing number of adults aged 65 and older are living with IBS.

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