"It was too much for me": mental load, mothers, and working from home during the COVID-19 pandemic.

This study analyses the experiences of working from home (WfH) during the COVID-19 pandemic and the impact it has on working mothers through the lens of "mental load." Remote study, often lauded as a way to reduce work/life conflicts, can bring new multifaceted challenges for working mothers and, as this study shows, suddenly shifting to remote work led to the boundaries among work, care, and domestic labour becoming blurred. The data used here are from narrative interviews collected as part of the RESpondIng to outbreakS through co-creaTIve inclusive equality stRatEgies (RESISTIRÉ) Horizon 2020 project, which analyses the impact of COVID-19 policies on gendered inequalities across the EU27 and Türkiye, Serbia, UK, and Iceland.

Effects of long-term feed deprivation on body weight loss, muscle composition, plasma metabolites, and intermediate metabolism of meagre (Argyrosomus regius) under different water temperatures.

The effect of feed deprivation at four water temperatures (17, 20, 23, 26 °C) was investigated in meagre (Argyrosomus regius) of initial mean weight ± SD, 116.16 ± 4.74 g, in triplicate groups.

Liver Transplantation for Acute Intermittent Porphyria: Biochemical and Pathologic Studies of the Explanted Liver.

Acute intermittent porphyria (AIP) is an autosomal-dominant hepatic disorder caused by the half-normal activity of hydroxymethylbilane (HMB) synthase. Symptomatic individuals experience life-threatening acute neurovisceral attacks that are precipitated by factors that induce the hepatic expression of 5-aminolevulinic acid synthase 1 (ALAS1), resulting in the marked accumulation of the putative neurotoxic porphyrin precursors 5-aminolevulinic acid (ALA) and porphobilinogen (PBG). Here, we provide the first detailed description of the biochemical and pathologic alterations in the explanted liver of an AIP patient who underwent orthotopic liver transplantation (OLT) due to untreatable and debilitating chronic attacks.

Diagnosis of feline acute intermittent porphyria presenting with erythrodontia requires molecular analyses.

Erythrodontia is the hallmark of human congenital erythropoietic porphyria (CEP), but is also a major phenotypic feature of acute intermittent porphyria (AIP) in cats. In this study, detailed biochemical and molecular analyses were performed on two unrelated cats with autosomal dominant AIP that presented with erythrodontia, yellow-brown urine and mild changes in erythrocytes. The cats had elevated concentrations of urinary 5-aminolevulinic acid and porphobilinogen, and half normal erythrocytic hydroxymethylbilane synthase (HMBS) activity.

Congenital erythropoietic porphyria: characterization of murine models of the severe common (C73R/C73R) and later-onset genotypes.

Congenital erythropoietic porphyria (CEP) is an autosomal recessive disorder due to the deficient activity of uroporphyrinogen III synthase (UROS). Knock-in mouse models were generated for the common, hematologically severe human genotype, C73R/C73R, and milder genotypes (C73R/V99L and V99L/V99L). The specific activities of the UROS enzyme in the livers and erythrocytes of these mice averaged approximately 1.