Publications by authors named "S Claeyssens"
Background: Women with hereditary fibrinogen disorders (HFDs) seem to be at an increased risk of adverse obstetrical outcomes, but epidemiologic data are limited.
Objectives: We aimed to determine the prevalence of pregnancy complications; the modalities and management of delivery; and the postpartum events in women with hypofibrinogenemia, dysfibrinogenemia, and hypodysfibrinogenemia.
Methods: We conducted a retrospective and prospective multicentric international study.
Background: Nonacog alfa, a standard half-life recombinant factor IX (FIX), is used as a prophylactic treatment in severe haemophilia B (SHB) patients. Its half-life determined in clinical studies involving a limited sampling (72 h) was shown to be rather short. In our clinical practice, we suspected that its half-life could have been underestimated.
View Article and Find Full Text PDFBackground: Data are limited on prostate cancer (PC) management in patients with haemophilia (PWH).
Aim: To describe PC screening and diagnosis, treatment modalities and bleeding complications in a group of unselected PWH followed at French Haemophilia Treatment Centres (HTCs) PATIENTS AND METHODS: PC screening, management and bleeding complications were retrospectively investigated at 14 French HTCs between 2003 and 2018.
Results: Among> 1549 > 50-year-old PWHs, 73 (4.
Article Synopsis
- The study assessed how well guidelines for early long-term prophylaxis in infants with severe hemophilia A were followed and identified factors impacting this compliance.
- Nearly 333 boys were included, showing a significant increase in prophylaxis use (61.2%) compared to a historical group (9.5%) before the guidelines were implemented.
- Factors like the location of hemophilia treatment centers and age at the time of prophylaxis indication were linked to timely treatment, while early bleeding issues and inhibitor development led to guideline inapplicability in some cases.
- Overall, while the guidelines appear to boost prophylaxis use, challenges in starting treatment early still exist.
Background: Despite a high prevalence of angiodysplasia, no specific guidelines are available for the modalities of endoscopic exploration of gastrointestinal (GI) bleeding in von Willebrand disease (VWD). Whether VWD patients could benefit from video capsule endoscopy (VCE) looking for angiodysplasia eligible to endoscopic treatment or at high risk of bleeding is unknown.
Objectives: To assess the diagnostic efficacy for angiodysplasia and the prognostic value of VCE on top of conventional endoscopy in VWD patients with GI bleeding.