Publications by authors named "S Chwiesko"
Purpose: The optimal treatment of systemic sclerosis (SSc) is a challenge because the pathogenesis of SSc is unclear and it is an uncommon and clinically heterogeneous disease affecting multiple organ systems. The aim of the European League Against Rheumatism (EULAR) Scleroderma Trials and Research group (EUSTAR) was to develop evidence-based, consensus-derived recommendations for the treatment of SSc.
Methods: To obtain and maintain a high level of intrinsic quality and comparability of this approach, EULAR standard operating procedures were followed.
Objective: To describe methods and procedures used for the development of the European League Against Rheumatism (EULAR)/EULAR Scleroderma Trial and Research group (EUSTAR) recommendations for the treatment of systemic sclerosis. In particular, the results of a web-based Delphi exercise aimed at selection of research questions and evidence from systematic literature research, as parts of the development of these recommendations, are presented in detail.
Methods: In agreement with the EULAR standard operating procedures a Task Force was created that consisted of the EUSTAR board members, 10 systemic sclerosis (SSc) experts invited from outside the EUSTAR board and representing Europe, the USA and Japan, a clinical epidemiologist, 2 patients with SSc and 3 fellows for literature research.
Article Synopsis
- Systemic sclerosis (SSc) is a chronic auto-immune disease that leads to skin thickening, organ dysfunction, and blood vessel issues.
- The study aimed to analyze the causes of death in SSc patients and assess how clinical status and immunological tests relate to their survival.
- Findings showed that 17.1% of the studied 76 SSc patients died, primarily due to interstitial lung disease (30%) and neoplasms (23.1%), highlighting pulmonary complications and the presence of pleural exudation as significant risk factors for mortality.
[Cyclophosphamide treatment in patients with systemic sclerosis].
Postepy Hig Med Dosw (Online)
October 2006
Systemic sclerosis (SSc) is a chronic, multisystemic, connective tissue disease characterized by fibrosis of the skin and visceral organs and the impairment of blood vessels. The etiology of SSc is unknown and its pathogenesis unclear. Effective treatment of SSc is also unavailable.
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