Publications by authors named "S Christophe"
Objective: Today, there is only limited knowledge of the spatial organization of hair chemistry. Infrared microspectroscopy is a well-established tool to provide such information and has significantly contributed to this field. In this study, we present new results combining multiple infrared microspectroscopy methods at different length scales to create a better chemical histology of human hair, including the hair follicle, hair shaft, hair medulla and hair cuticle.
View Article and Find Full Text PDFManure from bovine farms is commonly used as an organic fertiliser. However, if not properly managed, it can spread significant biological and chemical hazards, threatening both human and animal health. The effectiveness of risk control hugely relies on farmers' knowledge regarding safe manure management and on the application of suitable management practices.
View Article and Find Full Text PDFProline conformational isomerization is a mechanism that affects different types of protein functions and behaviors. Using analytical characterization, structural analysis, and molecular dynamics simulations, we studied the causes of an aberrant two-peak size-exclusion chromatography profile observed for a trispecific anti-HIV antibody. We found that proline isomerization in the tyrosine-proline-proline (YPP) motif in the heavy chain complementarity-determining region (CDR)3 domain of one of the antibody arms (10e8v4) was a component of this profile.
View Article and Find Full Text PDFIntroduction: Telemedicine is a rapidly growing new mode of healthcare practice. It is particularly used and needed in remote areas in Lorraine (North East of France) that currently face a shortage of general practitioners and specialists. The objective of this study was to analyse general practitioner’s representations of telemedicine and teleconsultation.
View Article and Find Full Text PDFArticle Synopsis
- Low molecular weight heparins (LMWH) are often used in ICU for preventing blood clots and treating blood clot disorders during renal replacement therapy (RRT).
- A rare side effect of LMWH can be skin necrosis at injection sites, which may indicate an immunoallergic reaction known as heparin-induced thrombocytopenia (HIT).
- In a reported case, a patient developed skin necrosis after RRT without showing low platelet counts, and various tests were suggested to help diagnose the condition, given the low likelihood indicated by the 4T's scoring system.