Publications by authors named "S Chrisafi"
Ten-year clinical outcome, toxicity and compliance of dose-dense sequential adjuvant administration of cyclophosphamide & epirubicin followed by docetaxel in patients with early breast cancer: A hellenic cooperative oncology group observational study (HE 10/10) with concurrent investigation of significance of tumor infiltrating lymphocytes.
Breast
February 2024
Article Synopsis
- Dose-dense sequential (dds) chemotherapy has positively impacted long-term survival rates in early breast cancer patients, as shown in the observational trial HE 10/10.
- The study analyzed the role of tumor infiltrating lymphocytes (TILs) and CD8 lymphocytes in predicting outcomes, finding that higher levels are linked to better survival.
- With a median follow-up of over 10 years, the study reported disease-free survival (DFS) at 78.4% and overall survival (OS) at 81.7%, highlighting the regimen's efficacy and safety.
Article Synopsis
- A study investigated the role of CD8+ tumor-infiltrating lymphocytes (TILs) in early breast cancer patients who received adjuvant chemotherapy, revealing important prognostic implications based on their density in tumors.
- Out of 928 patients, 627 had CD8+ data, with about 25% showing high levels of CD8 TILs, which were linked to more aggressive tumor characteristics and better survival rates.
- High intratumoral (iCD8) and total (tCD8) counts were associated with longer disease-free survival (DFS) and overall survival (OS), indicating their potential as beneficial prognostic factors in managing early breast cancer.
Prognostic and predictive biomarkers are being studied for the diagnosis and treatment of breast cancer. The present study retrospectively assessed the mRNA expression of HER family receptor ligands and of other potential prognostic biomarkers and their association with time to progression (TTP), survival and clinicopathological characteristics in patients with metastatic breast cancer (MBC) treated with trastuzumab. A total of 145 tumour tissue samples were analysed.
View Article and Find Full Text PDFPurpose: Angiogenesis is a crucial phenomenon in the development and progression of breast cancer (BC), but the clinical significance of angiogenesis-related proteins in metastatic BC remains unknown. This study investigates the prognostic value of vascular endothelial growth factor receptors 1, 2, 3 (VEGFR1, VEGFR2, VEGFR3) as well as vascular endothelial growth factors A and C (VEGFA and VEGFC) in metastatic BC patients treated with trastuzumab-based regimens.
Materials And Methods: Two hundred female patients were included.
Purpose: The genomic status of non-malignant tissues from carriers of pathogenic germline BRCA1/2 (gBRCA1/2) variants may reveal information towards individualized prophylaxis. We performed spatiotemporal tissue genotype comparisons in a real-life cohort of gBRCA1/2 carriers of Greek origin, who underwent multiple risk-reducing/prophylactic surgeries at various time points.
Methods: Fifty-three women (median age 36 years) within cancer families were observed for up to 37.