Publications by authors named "S Choy"
Article Synopsis
- Researchers typically follow a two-step statistical process: conducting power analyses before collecting data and significance tests afterward.
- Critics argue that significance tests offer limited insights and can easily be misused in research.
- A proposed improved approach suggests replacing traditional power analysis with parameter estimation before data collection, and focusing on estimating probabilities of outcomes (better or worse) after data collection for more informative results.
Background: This study sought to answer the following questions: (1) Are there differences in knowledge on time to treatment (TTT) between stroke, myocardial infarction (MI), and hip fractures in the general population? (2) Are there differences in condition-specific knowledge across these conditions? (3) Are there underlying demographic factors that may contribute to differences in hip fracture-specific knowledge?
Materials And Methods: This was a cross-sectional cohort analysis. Participants were acquired using an online survey distribution platform, Amazon Mechanical Turk (MTurk). Individuals older than 18 years with English fluency and literacy were included.
Article Synopsis
- The study aims to evaluate the pharmacokinetics and pharmacodynamics of nedosiran in patients with primary hyperoxaluria type 1 (PH1), identifying important variables and confirming effective dosing.
- A population pharmacokinetic/pharmacodynamic model was created to analyze how nedosiran behaves in the body and its impact on urinary oxalate levels over a 24-hour period, using data from healthy individuals and PH1 patients.
- Results indicated a weight-based dosing strategy for adolescents and adults, demonstrating that a significant percentage of PH1 patients achieved normal urinary oxalate levels after treatment, confirming the model's effectiveness in guiding dosing.
The commonality between various muscle diseases is the loss of muscle mass, function, and regeneration, which severely restricts mobility and impairs the quality of life. With muscle stem cells (MuSCs) playing a key role in facilitating muscle repair, targeting regulators of muscle regeneration has been shown to be a promising therapeutic approach to repair muscles. However, the underlying molecular mechanisms driving muscle regeneration are complex and poorly understood.
View Article and Find Full Text PDFUnderstanding the phenotypic consequences of naturally occurring genetic changes, as well as their impact on fitness, is fundamental to understanding how organisms adapt to an environment. This is critical when genetic variants have pleiotropic effects, as determining how each phenotype impacted by a gene contributes to fitness is essential to understand how and why traits have evolved. A striking example of a pleiotropic gene contributing to trait evolution is the gene, coding mutations in which underlie albinism and reductions of sleep in the blind Mexican cavefish, .
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