Systemic fentanyl enhances the spread of spinal analgesia produced by lignocaine.

Seventy-one patients undergoing transurethral prostatectomy under spinal anaesthesia were allocated randomly to one of four groups; fentanyl-naloxone (F-Nal), fentanyl-normal saline (F-NS), normal saline-naloxone (NS-Nal), and normal saline-normal saline (NS-NS) group. Twenty minutes after subarachnoid injection of hyperbaric lignocaine 100 mg, we tested the level of spinal analgesia (pinprick sensation) and administered i.v.

Effect of hypercapnea and hyperventilation on human intraocular pressure general anaesthesia following acetazolamide administration.

The changes in intraocular pressure due to blood pH, PCO2, and PO2 alterations induced by hyperventilation and hypercapnea in man undergoing routine general anaesthesia were studied. It was shown that hypercapnea produces elevation of intraocular pressure, while hyperventilation lowers it. Acetazolamide pretreatment did not alter these IOP responses to PCO2, PO2, and blood pH changes.