Publications by authors named "S Chokshi"
Bacterial translocation-induced inflammation and immune dysfunction are recognised factors contributing to the pathogenesis of primary biliary cholangitis (PBC). However, the specific involvement of interferons (IFNs) and soluble checkpoints (sol-CRs) in shaping the immune landscape in PBC patients remains unexplored. Furthermore, the influence of ursodeoxycholic acid (UDC) on these immune mediators is unknown.
View Article and Find Full Text PDFIn this position statement, we explore the intricate relationship between alcohol intake and metabolic dysfunction in the context of the 2023 nomenclature update for steatotic liver disease (SLD). Recent and lifetime alcohol use should be accurately assessed in all patients with SLD to facilitate classification of alcohol use in grams of alcohol per week. Alcohol biomarkers (i.
View Article and Find Full Text PDFBackground: Alcohol use is the third leading risk factor of death and disability in the UK and costs the NHS £3.5 billion per year. Despite the high prevalence and healthcare burden of Alcohol-related Liver Disease (ArLD), there has been minimal research addressing prevention, morbidity and mortality.
View Article and Find Full Text PDFThe NCCN Guidelines for the Management of Immunotherapy-Related Toxicities are intended to provide oncology practitioners with guidance on how to manage the wide-ranging and potentially fatal toxicities that may occur with cancer immunotherapy. The guidelines address immune-related adverse events related to immune checkpoint inhibitors, CAR T-cell therapies, and lymphocyte engagers (which include T-cell-engaging bispecific antibodies). These NCCN Guidelines Insights highlight recent guideline updates pertaining to the management of emerging toxicities related to cancer immunotherapy.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how the gut and oral microbiomes are affected in patients with varying severities of cirrhosis, focusing on the presence of harmful bacteria and resistance genes.
- It involves analysis of samples from multiple groups: healthy controls, stable cirrhosis, decompensated cirrhosis, acute-on-chronic liver failure patients, and those with severe infections but no cirrhosis.
- Results show increased overlap of oral and gut microbiomes and greater amounts of virulence factors and antibiotic resistance genes as cirrhosis severity increases, suggesting a shift towards more harmful bacteria and a loss of beneficial ones.