A focus on phosphinophosphination of apolar bonds by a structurally constrained P-P bonded system.

In this article, we highlight the recent report of Greb on the use of a structurally constrained P-P bonded system for phosphinophosphination of alkenes, alkynes, and carbonyls with high regio- and stereoselectivity (https://doi.org/10.1039/D4SC06581F).

Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent "Type V" Kinase Inhibitors.

Binding multiple sites within proteins with bivalent compounds is a strategy for developing uniquely active agents. A new class of dual-site inhibitors has emerged targeting the epidermal growth factor receptor (EGFR) anchored to both the orthosteric (ATP) and allosteric sites. Despite proof-of-concept successes, enabling selectivity against oncogenic activating mutations has not been achieved and classifying these inhibitors among kinase inhibitors remains underexplored.

Health Systems for Rehabilitation - Critical Appraisal of the National Programme for Stroke in India.

The organized provision of health services in India has been envisioned since 1946 by the recommendations from the Bhore committee. However, the policy and program strategies for the provision of good quality health care still lack effectiveness. Access to rehabilitation services for persons with disabilities continues to be a significant public health problem in India.

Influence of Pnictogen and Ligand Framework on the Lewis Acidity and Steric Environment in Pnictogen Pincer Complexes.

Pnictogen pincer complexes are a fascinating class of compounds due to their dynamic molecular and electronic structures, and valuable stoichiometric or catalytic reactivity. As recognition of their unique chemistry has grown, so too has the library of pincer ligands employed and pnictogen centres engaged to prepare them. Here we computationally study how the choice of pincer ligand framework and pnictogen influence the electronic and steric outcomes within the complexes obtained.