Publications by authors named "S Chinnakotla"
A 5-month-old child developed severe liver dysfunction after a liver transplant with a partial liver graft. Ultrasound examination revealed a communication between the left portal vein and the left hepatic vein, a rare congenital portosystemic shunt. Here we describe the successful management of this shunt with an endovascular closure device.
View Article and Find Full Text PDFThe opioid crisis has emphasized identification of opioid-sparing analgesics. This study was designed as a prospective trial with retrospective control group to determine feasibility for implementing a high-dose prolonged magnesium sulfate infusion for adjuvant analgesia in the pediatric intensive care unit. Approval was granted for study of children receiving total pancreatectomy with islet cell autotransplantation and liver transplantation ages 3-18 years.
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- Chronic pancreatitis (CP) increases the likelihood of developing calcium-oxalate kidney stones, and this study focuses on assessing that risk in patients who have undergone total pancreatectomy with islet autotransplantation (TPIAT).
- A retrospective analysis of 629 TPIAT patients found that the risk for kidney stones is significant, with about 29.4% experiencing at least one episode within 15 years post-surgery.
- Key factors associated with increased kidney stone risk included older age, smoking, mild chronic kidney disease, and a history of kidney stones or renal cysts, highlighting the need for clinician awareness and patient counseling on preventative measures.
Background: Liver transplantation for inborn errors of metabolism is increasingly common and has historically had positive outcomes. However, this therapeutic modality is not without risks, and patient post-transplant quality of life should be part of the consideration.
Methods: This retrospective, observational cohort study included all pediatric patients receiving liver transplant from 2010 through 2020 at a single center.
Background: In total pancreatectomy with islet autotransplantation (TPIAT), a greater number of islets transplanted produces more favorable outcomes. We aimed to determine predictors of islet isolation outcomes.
Methods: We investigated factors associated with islet isolation outcomes expressed as islet number (IN), islet equivalents (IEQ; standardized to an islet with 150 μm diameter), IN/kg, or IEQ/kg using data from the multicenter Prospective Observational Study of TPIAT.