Publications by authors named "S Chernushyn"
Article Synopsis
- The study aimed to identify and analyze the variants of SARS-CoV-2 in COVID-19 patients from different regions of Ukraine, focusing on the relationship between virus genetics and COVID-19 spread.
- Samples were collected from 401 patients during 2021-2022, and whole genome sequencing was used for genotyping SARS-CoV-2 variants.
- Results revealed three main variants (Alpha, Delta, and Omicron) across three pandemic waves, each with distinct genetic changes and epidemiological patterns, indicating effective anti-epidemic measures in Ukraine despite low vaccination rates.
We assessed the predictive ability of a combined genetic variant panel for the risk of recurrent pregnancy loss (RPL) through a case-control study. Our study sample was from Ukraine and included 114 cases with idiopathic RPL and 106 controls without any pregnancy losses/complications and with at least one healthy child. We genotyped variants within 12 genetic loci reflecting the main biological pathways involved in pregnancy maintenance: blood coagulation (, , , ), hormonal regulation (, ), endometrium and placental function (, ), folate metabolism () and inflammatory response (, , ).
View Article and Find Full Text PDFThe aim of this study was to examine association between IFNL4 gene ss469415590 and treatment efficiency in group of Ukrainian PEG-interferon/ribavirin-treated chronic hepatitis C patients. Study group consisted of 92 unrelated hepatitis C virus genotype 1 mono-infected patients: case group - 29 patients with late or absent virological response; control group - 63 patients with sustained virological response. Study material was genomic DNA.
View Article and Find Full Text PDFIn the article the data on the distribution of CYP21A2 gene mutations (gene deletion/conversion, c.290-13C>A/G, E110Vfs, I172N, cluster of mutations I236N, V237E, M239K, V281L, Q318X, R356W) among Ukrainian patients with congenital adrenal hyperplasia of different clinical phenotypes are presented. The most common mutation in the studied group (n = 27) is the CYP21A2 gene deletion/conversion.
View Article and Find Full Text PDFThe aim of this study was to examine association between gene ss469415590 and treatment efficiency in group of Ukrainian PEG-interferon/ribavirin-treated chronic hepatitis C patients. Study group consisted of 92 unrelated hepatitis C virus genotype 1 mono-infected patients: case group-29 patients with late or absent virological response; control group-63 patients with sustained virological response. Study material was genomic DNA.
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